منابع مشابه
INHIBITION OF14C UPTAKE BY CANDIDA ALBICANS: A NEW METHOD FOR INVESTIGATION OF INTRACELLULAR KILLING BY PHAGOCYTES
A radio assay employing 14C-uridine to measure the intracellular killing of Candida albicans by phagocytes is presented. The principle of this new method is that after killing of Candida albicans by phagocytes RNA synthesis stops and therefore uridine uptake is diminished whilst viable candida in cultures would take up uridine and as a result, high CPM counts can be obtained within 135 min...
متن کاملLandscape review of current HIV ‘kick and kill’ cure research - some kicking, not enough killing
BACKGROUND Current antiretroviral therapy (ART) used to treat human immunodeficiency virus (HIV) patients is life-long because it only suppresses de novo infections. Recent efforts to eliminate HIV have tested the ability of a number of agents to reactivate ('Kick') the well-known latent reservoir. This approach is rooted in the assumption that once these cells are reactivated the host's immune...
متن کاملCell killing by lysosomotropic detergents
We have studied the mechanism by which lysosomotropic detergents kill baby hamster kidney cells. Lysosomotropic detergents are lysosomotropic amines (compounds with pK between 5 and 9, such as imidazole or morpholine) containing straight-chain hydrocarbon "tails" of 9-14 carbon atoms (Firestone, R. A., J. M. Pisano, and R. J. Bonney. 1979, J. Med. Chem., 22:1130-1133). Using lucifer yellow CH a...
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Background and objectives: Ziziphora tenuior is considered as an appropriate protoscolicidal agent yet the mechanism of such effect is not known so far. The aim of this study was to evaluate the apoptotic effect of Z. tenuior extract on protoscolices of hydatid cyst. Methods: Protoscolices were collected aseptically and the Bradford test was e...
متن کاملKilling begets killing: evidence from a bug-killing paradigm that initial killing fuels subsequent killing.
Killing appears to perpetuate itself even in the absence of retaliation. This phenomenon may occur in part as a means to justify prior killing and so ease the threat of prior killing. In addition, this effect should arise particularly when a killer perceives similarity to the victims because similarity should exacerbate threat from killing. To examine these ideas, the authors developed a bug-ki...
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ژورنال
عنوان ژورنال: Nature
سال: 2015
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature16321